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‘Mystical’ psychedelic compound found in normal brains
July 22, 2019

‘Mystical’ psychedelic compound found in normal brains

Summary: DMT, an active compound of the psychedelic Ayahuasca, is naturally occurring in the mammalian brain, researchers have discovered. The study revealed DMT levels increased significantly in the rat visual cortex following cardiac arrest.

Source: University of Michigan

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally used by indigenous people for sacred religious ceremonies. Drinkers of Ayahuasca experience short-term hallucinogenic episodes many describe as life-changing.

The active ingredient responsible for these psychedelic visions is a molecule called dimethyltryptamine (DMT). For the first time, a team led by Michigan Medicine has discovered the widespread presence of naturally-occurring DMT in the mammalian brain. The finding is the first step toward studying DMT– and figuring out its role — within the brains of humans.

“DMT is not just in plants, but also can be detected in mammals,” says Jimo Borjigin, Ph.D., of the Department of Molecular and Integrative Physiology. Her interest in DMT came about accidentally. Before studying the psychedelic, her research focused on melatonin production in the pineal gland.

In the seventeenth century, the philosopher Rene Descartes claimed that the pineal gland, a small pinecone-shaped organ located deep in the center of the brain, was the seat of the soul. Since its discovery, the pineal gland, known by some as the third eye, has been shrouded in mystery. Scientists now know it controls the production of melatonin, playing an important role in modulating circadian rhythms, or the body’s internal clock. However, an online search for notes to include in a course she was teaching opened Borjigin’s eyes to a thriving community still convinced of the pineal gland’s mystical power.

The core idea seems to come from a documentary featuring the work of researcher Rick Strassman, Ph.D. with the University of New Mexico School of Medicine. In the mid-1990s, he conducted an experiment in which human subjects were given DMT by IV injection and interviewed after its effects wore off. In a documentary about the experiment, Strassman claims that he believed the pineal gland makes and secretes DMT.

“I said to myself, ‘wait, I’ve worked on the pineal gland for years and have never heard of this,'” she said. She contacted Strassman, requesting the source of his statement. When Strassman admitted that it was just a hypothesis, Borjigin suggested they work together to test it. “I thought if DMT is an endogenous monoamine, it should be very easy to detect using a fluorescence detector.”

Using a process in which microdialysis tubing is inserted into a rat brain through the pineal gland, the researchers collected a sample that was analyzed for — and confirmed — the presence of DMT. That experiment resulted in a paper published in 2013.

This shows a brain against a psychedelic background

 

The finding is the first step toward studying DMT– and figuring out its role — within the brains of humans. The image is in the public domain.

However, Borjigin was not satisfied. Next, she sought to discover how and where DMT was synthesized. Her graduate student, Jon Dean, lead author of the paper, set up an experiment using a process called in situ hybridization, which uses a labeled complementary strand of DNA to localize a specific RNA sequence in a tissue section.

“With this technique, we found brain neurons with the two enzymes required to make DMT,” says Borjigin. And they were not just in the pineal gland.

“They are also found in other parts of the brain, including the neocortex and hippocampus that are important for higher-order brain functions including learning and memory.”

The results are published in the journal Scientific Reports.

Her team’s work has also revealed that the levels of DMT increase in some rats experiencing cardiac arrest. A paper published in 2018 by researchers in the U.K. purported that DMT simulates the near death experience, wherein people report the sensation of transcending their bodies and entering another realm. Borjigin hopes to probe further to discover the function of naturally occurring levels of DMT in the brain — and what if any role it plays in normal brain functions.

“We don’t know what it’s doing in the brain. All we’re saying is we discovered the neurons that make this chemical in the brain, and they do so at levels similar to other monoamine neurotransmitters.”

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Is it time to decriminalize psychedelic drugs?
July 22, 2019

Is it time to decriminalize psychedelic drugs?

Psychedelics are having a moment—again.

The Oakland, California city council resolved to decriminalize magic mushrooms on June. 5, becoming the second US city to do so after Denver, Colorado. Though some argue this is not the best approach to increase access, decriminalizing these drugs makes them safer for people who take them for their potential health benefits.

Psychedelics have a long history in clinical research, where they’ve shown an impressive ability to treat addiction, depression, and other mental health issues. The US Food and Drug Administration has designated MDMA-assisted psychotherapy as a breakthroughtreatment for PTSD, expediting its approval process. (While it’s not a “classical” psychedelic, MDMA is often considered a psychedelic because of its mind-altering properties.)

Watch the video above for a look at how researchers are rediscovering the value of psychedelics in mental health treatment, and how the drugs are already improving lives.

Click here to see the video.

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Astrix - BEST PSYTRANCE SONGS & ALBUMS
July 11, 2019

Astrix - BEST PSYTRANCE SONGS & ALBUMS

Avi Shmailov (Hebrew: אבי שמיילוב) under his stage name Astrix, has been one of the leading PsyTrance producers & DJs in the world for 15 years, carrying his musical message of psychedelic emotional uplifting trance to every corner of the world, to huge festivals (EDC, Burning Man, Boom Festival, Tomorrowland, Ozora, Universo Paralello, XXXperience), to the biggest urban clubs (Brixton Academy, Ministry of Sound, O2 Arena, Pacha, Privilege) & underground events.

Astrix released five full-length studio albums at the record label Hom-Mega production based in Israel,

In his albums Astrix collaborated with artists who were also involved in the Pytrance scene, such as Infected Mushroom, Atomic Pulse, Domestic, Sub6, Psycraft, Xerox and Illumination.

Some best of psytrance songs by Astrix:

 

SAHARA

 

DEEP JUNGLE WALK

 

MOONSHINE

 

ADHANA

 

CHECK OUT BELOW SOME PSYTRANCE ALBUMS FROM ASTRIX.

 

Eye to Eye Album from Astrix 2002



Coolio Album from Astrix 2004

 

Artcore Album from Astrix 2004

 

Future Music Album from Astrix 2007

 

One Step Ahead Album from Astrix 2009

 

Acid Rocker Album from Astrix 2010

 

Red Means Distortion Album from Astrix 2010

 

High on Mel Album from Astrix 2013

 

Remixed Album from Astrix 2013

 

He.art Album from Astrix 2016

 

Astrix Boom Festival 2018

 

Astrix Adhana Festival 2018-2019

 

Follow Astrix:

Instagram: https://www.instagram.com/astrixofficial/

Facebook: https://www.facebook.com/Astrix.Official

Soundcloud: https://soundcloud.com/astrix-official

Mixcloud: https://www.mixcloud.com/AstrixOfficial/

Twitter: https://twitter.com/astrixofficial

 

www.acidmath.me

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