Can Ketamine Cure Depression?

Posted by Bill Kovski on

There are at least 300 millions people in the world suffering from depression. Depression is the leading cause of suicides. The underlying cause of it is essentially negative thought cycles. Traditional methods of treating depression are not necessarily very effective. CBT (Cognitive behavioural therapy) and anti-depressants can be very helpful, but not in all cases and not to a great extent.
And this is where hallucinogens come in. Some hallucinogens allow the user to get rid of old negative neurological pathways and develop new positive ones.

LSD and psilocybin mushrooms, mostly, were once used in western psychiatry, but are now illegal and usually frowned upon. However, there is a hallucinogen that is legal for medicinal purposes and is used frequently.



You see, in 1950’s, there was a drug called phencyclidine (PCP). It was a dissociative which was primarily used as an anesthetic. But it’s side effects quickly became known and it was made illegal and it was no longer used in medicine. A new anesthetic had to be made in order to replace it. And it was made and called ketamine.

Ketamine is a powerful dissociative hallucinogen which is being used mostly as an anesthetic, but it also pretty recently became known as a drug which helps to treat depression.

How Does It Work?

How does it do that, you might ask? Well, the fact of the matter is that we don’t know too much about it, but it seems that people who have major depression have abnormalities in the glutaminergic signaling. Ketamine is an NMDA  (Glutamate N-Methyl-D-aspartate) receptor antagonist, which seems to explain why it helps with depression, since it helps to improve glutaminergic signaling. This in turn helps the user to form new neurological pathways in the brain, that lead to him or her becoming happier and more functional.


Here’s a few stories of people successfully having used ketamine to treat depression:

Jeff Ellis suffered from severe depression for many years leading up to his complete mental collapse. Being suicidal and seemingly hopeless, be decided to go to a ketamine clinic in California and it has changed his entire life. Here’s a video of his story:



Here’s another story. This man has lost both of his sons to suicide, which led to him developing deep depression with suicidal thoughts. He was hopeless and lacking the will to live – until he started ketamine treatment:


Here’s the last video from VICE, about a man who was molested as a child and who suffered from depression ever since:


Depression is a horrific mental disorder which, responsible for millions of suicides and general unhappiness and emptiness of life in hundreds of millions of people. Ketamine has it’s dangers, but used medicinally, in some cases, under supervision of medical professionals, it can save lives, as most anti depressants, take weeks to begin working, which is too long for some deeply depressed individuals, and also a huge segment of the patients don’t respond to anti-depressant treatment at all. Ketamine on the other hand works instantaneously and is incredibly effective, with as little as a single intravenous ketamine injection leading to a significant reduction in the suicidal thoughts and depression in about 50% of the severely depressed people, in one study. And that is why ketamine clinics are opening all over the world and treating people who are depressed, but also suffer from anxiety and other disorders.


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